A SMALL-SCALE University of California, San Francisco UCSF), United States-led study has identified the first evidence in humans that exposure to bisphenol A (BPA) may compromise the quality of a woman?s eggs retrieved for in vitro fertilisation (IVF).
As blood levels of BPA in the women studied doubled, the percentage of eggs that fertilised normally declined by 50 per cent, according to the research team.
The chemical BPA, which makes plastic hard and clear, has been used in many consumer products such as reusable water bottles. It also is found in epoxy resins, which form a
protective lining inside metal food and beverage cans.
?While preliminary, the data indicate the negative effect of BPA on reproductive health and the importance of allocating more funding to further investigate why such environmental contaminants might be disrupting fertility potential,? said Prof. Victor Y. Fujimoto, lead study author and professor in the UCSF Department of Obstetrics, Gynecology, and Reproductive Sciences, who also is on the faculty of the UCSF Center for Reproductive Health.
Findings are available online in the journal Fertility and Sterility at http://j.mp/fyjTFF.
In the study, BPA levels and fertilisation rates were analysed for 26 women undergoing IVF during 2007 and 2008 at the UCSF Center for Reproductive Health.
The women were a subgroup of a larger study evaluating the effect on reproductive health of trace exposures to toxic metals ? mercury, cadmium and lead.
?Given the widespread nature of BPA exposure in the U.S., even a modest effect on reproduction is of substantial concern,? said Michael S. Bloom, PhD, senior author and an assistant professor in the Departments of Environmental Health Sciences, and Epidemiology and Biostatistics at the School of Public Health of the University at Albany, State University of New York.
The Centers for Disease Control and Prevention found BPA in the urine of nearly everyone tested in a 2004 analysis of the U.S. population.
BPA is gaining global attention as an environmental contaminant that impacts health owing to its widespread exposure and endocrine-disrupting properties, according to the researchers.
An endocrine disruptor is a synthetic chemical that when absorbed into the body either mimics or blocks hormones and interferes with the body?s normal functions.
Previous studies in mouse models have indicated that BPA levels alter the DNA of eggs, and a 2010 study in humans demonstrated BPA urinary concentrations to be inversely associated with the number of eggs retrieved during an IVF cycle.
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